![]() This difference was statistically significant. In group 2 at baseline mean BMC was 158+93.88 and after 1 year mean BMC was 231+103.79. This difference was found to be statistically significant. In group 1, at baseline mean BMC was 140.88+56.27 and after 1 year mean BMC was 206.4+59.83. But the comparison between the different groups for percentage increment in BMD was not found to be statistically significant. There was a 7.9% and 1.28% increase in the mean BMD after vitamin D supplementation in groups 2 and 3, respectively. Similarly in groups 2 and 3 the difference between mean BMD at baseline and at 1 year was found to be statistically significant. ![]() There was a 3.63% increase in the mean BMD after vitamin D supplementation in group 1 ( Tables 5, 6, 7). In group 1, at baseline mean BMD was 0.522+0.028 and after 1 year mean BMD was 0.541+0.021. It was a single blind study and patients involved in the study were unaware of assignment to treatment groups. The randomization lists were computer-generated prior to the start of the study and kept confidential. After 3 months and 12 months, their serum vitamin D was measured. After completion of 3 regimens, children of each group received maintenance dose of 400 IU/day vitamin D3 along with calcium (50 mg/kg/day). Calcium carbonate was the calcium preparation used in the dosage of 50-mg elemental calcium/kg/day). Group 1 received 4,000 IU/day of vitamin D3 for 12 weeks along with calcium carbonate (50-mg elemental calcium/kg/day), group 2 received 30,000 IU/wk of vitamin D3 for 12 weeks along with calcium carbonate (50-mg elemental calcium/kg/day), and group 3 received 3,00,000 IU of vitamin D3 once intramuscular along with calcium carbonate (50-mg elemental calcium/kg/day). ![]() Stratified randomization with a block size of 3 was used to assign patients to groups 1, 2, and 3. Subjects eligible for the study were divided in 2 strata based on gender (male or female).
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